Science
Inspired by nature : Ceragenins are synthetic non-peptide small molecules modeled after host defense peptides, vital components of our innate immune system. Ceragenins mimic and enhances LL-37, reduce and inhibit IL-6, without creating antimicrobial resistance
Unique capabilities : They exhibit an array of pharmacological activities, including antimicrobial and anti-inflammatory effects, similar to their natural counterparts.
Proven and patented : Backed by extensive research (Since 2019 there have been 350 peer-reviewed journal articles about the Ceragenins technology), patents, and significant investments, Ceragenins are a breakthrough in medical science.
Structure: Featuring a sterol backbone adorned with amino acids and other groups, they have a positive charge that targets the negatively charged cell membranes of many pathogens.
LL-37 – inspired by nature
- LL-37 is the only human member of the cathelicidin family of antimicrobial peptides.
- A potent antimicrobial peptide with a broad activity spectrum. Effective against various bacteria, fungi, and lipid-enveloped viruses
- LL-37 is a natural first line defense against infection invasion of pathogens while promoting accelerated wound healing
- LL-37 is active against drug-resistant organisms & biofilms
- LL-37 is crucial for patients with Cystic Fibrosis (CF) due to its role in the innate immune system. It possesses broad-spectrum antimicrobial properties that help combat the persistent lung infections common in CF, caused by the thick mucus that traps bacteria and other pathogens.
Potent Antimicrobials: Beyond Conventional Approaches
Targeting membranes: Ceragenins disrupt microbial cell membranes rather than internal replication mechanisms, ensuring efficacy against a broad spectrum of pathogens.
- Combatting biofilms: Exceptional in preventing and eradicating resistant bacterial and fungal biofilms, unlike standard antibiotics.
- CSAs stand out with rapid, potent action against formidable pathogens, including MRSA and Pseudomonas.
Strong Anti-Inflammatory and Immunomodulatory Activities
- Mimicking natural peptides : Ceragenins parallel the properties of cathelicidin antimicrobial peptides in immune modulation.
- Diverse effects : They influence key cytokines (IL-6, TNF alpha), promote chemokine expression, and play roles in angiogenesis, apoptosis, and wound healing.
- Bacterial Resistance : A Minimal Concern. Ceragenins have minimal resistance potential due to their novel mechanism of action. Serial passaging studies (30x) show no mutational resistance and recent proteomics data shows that CSAs unique mechanism of action targets key components of conserved features of bacterial membranes.
- Novel action : Ceragenins’ unique approach minimizes the likelihood of bacterial resistance, supported by extensive passaging studies and proteomic data.
- Targeting bacterial membranes : Their mechanism disrupts conserved features of bacterial cell walls, a strategy less prone to resistance development.
Additional Value-Added Attributes
- Anti-biofilm excellence : Highly effective in both preventing and eradicating biofilms at low concentrations.
- Synergy with existing treatments : Demonstrated ability to enhance the efficacy of traditional anti-infectives.
- Resilience in challenging environments : Retains activity in cystic fibrosis mucus.
Lets Get in Touch!
- 1 (702) 285-5740
- info@kinnearpharma.com
- Fax: (877) 686-3318
- 3960 Howard Hughes Parkway, Las Vegas, NV, 89169
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